Startups Backed by Sequoia

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Sail Research

United States

Sail Research provides cloud infrastructure for running long-horizon AI agents, pairing cost-efficient serving of open-source language models with hosted sandboxes (Sailboxes) where agents execute. Its API is OpenAI- and Anthropic-compatible and offers "completion windows" that trade latency for cheaper tokens, and the platform has served trillions of tokens for use cases like code review, deep research, and cybersecurity. The company is based in San Francisco.

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Engram

United States

Engram is a US-based AI company building a "learned memory" layer that lets language models recall organization-specific context and workflows, claiming results comparable to frontier labs while using far fewer tokens. Founded in late 2025 by a team out of Stanford and Columbia, it targets enterprises looking to cut runaway AI inference costs.

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Probook

United States

Probook builds an AI operating system for home-services businesses, automating the dispatch workflow alongside intake, scheduling, data cleaning, and customer messaging for plumbing, HVAC, electrical, and maintenance providers. Founded by operators with trades backgrounds, it serves hundreds of locations nationwide, from independent shops to private-equity-backed platforms such as TurnPoint Services, Del-Air, and Peterman Brothers.

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Ent

United States

Ent is a San Francisco cybersecurity startup building an intent-aware workspace security platform that extends traditional endpoint protection into a real-time prevention layer for the AI-native enterprise. Its lightweight endpoint agent reads human, application, and AI-agent activity in real time and intervenes at the moment of risk based on customer-defined policy, rather than detecting incidents after the fact. The company was founded by RiskIQ veterans Elias Manousos and Brandon Dixon, who previously helped build Microsoft Security Copilot following Microsoft's 2021 acquisition of RiskIQ.

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NinjaOne

United States

NinjaOne provides a unified, automated endpoint management platform (RMM) that combines device visibility, patching, remote monitoring, vulnerability management, backup, and endpoint security into a single console. Its software targets IT teams and managed service providers, helping customers increase productivity, reduce operational risk, and simplify IT operations across Windows, macOS, Linux and mobile devices. The company serves enterprise and MSP customers globally and reports tens of thousands of customers across 140+ countries and significant annual recurring revenue as of FY2025.

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Garner Health

United States

Digital platform that helps patients find the best healthcare providers using better data and smarter financial incentives, leveraging large medical datasets to rank doctors and drive cost savings for employers.

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SendCutSend

United States

SendCutSend is a Reno, Nevada-based on-demand custom manufacturing company offering software-driven sheet-metal fabrication, laser cutting, and rapid-turnaround parts production. Customers upload CAD files and receive finished components in as little as 24 hours, serving robotics, defense, aerospace, and automotive customers across the United States.

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Commure

United States

At Commure, our mission is to simplify healthcare. We have bold ambitions to reimagine the healthcare experience, setting a new standard for how care is delivered and experienced across the industry. Our growing suite of AI solutions spans ambient AI clinical documentation, provider copilots, autonomous coding, revenue cycle management and more — all designed for providers & administrators to focus on what matters most: providing care. Healthcare is a $4.5 trillion industry with more than $500 billion spent annually on administrative costs, and Commure is at the heart of transforming it. We power over 500,000 clinicians across hundreds of care sites nationwide – more than $10 billion flows through our systems and we support over 100 million patient interactions. With new product launches on the horizon, expansion into additional care segments, and a bold vision to tackle healthcare's most pressing challenges, our ambition is to move from upstart innovator to the industry standard over the next few years. Commure was recently named to Fortune’s Future 50 list for 2025 and is backed by world-class investors including General Catalyst, Sequoia, Y Combinator, Lux, Human Capital, 8VC, Greenoaks Capital, Elad Gil, and more. Commure has achieved over 300% year-over-year growth for the past two years and this is only the beginning. Healthcare's moment for AI-powered transformation is here, and we're building the technology to power it. Come join us in shaping the future of healthcare.

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Full-Life Technologies

Belgium

Full-Life Technologies is a fully integrated global radiotherapeutics company with operations in Belgium, Germany, and China. The company focuses on radiopharmaceutical research, development, production, and commercialization, aiming to deliver clinical impact for patients through innovative treatments.